Polygala tenuifolia May Attenuate Cognitive Deficits, New Study Shows

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Polygala tenuifolia and OM! Mood Support from Linden Botanicals

In the study, published in BMC Complementary Medicine and Therapies, Polygala tenuifolia attenuated cognitive deficits by rescuing hippocampal neurogenesis.

Polygala tenuifolia provides mood support and has potential as an antidepressant. It's exciting to learn it may also promote neurogenesis, the process by which new neurons are formed in the brain.”

— Michael Van der Linden, Owner of Linden Botanicals

DENVER, COLORADO, UNITED STATES, November 18, 2021 /EINPresswire.com/ -- A study published on October 25, 2021, in BMC Complementary Medicine and Therapies revealed that a constituent of Polygala tenuifolia has the potential to reduce cognitive deficits. In the study, the constituent, 3,6'-disinapoyl sucrose (DISS), triggered a potent increase of hippocampal neurogenesis in a mouse model of Alzheimer's disease. DISS strengthened APP-neural stem cell proliferation and neuronal differentiation, and DISS treatment for four weeks showed the capability to attenuate cognitive deficits, neuronal injures, and neurogenesis disorder.

The study investigated the effects of DISS and two other active constituents of Polygala tenuifolia on the proliferation and differentiation of neural stem cells to identify the potential active constituent of Polygala tenuifolia that promote hippocampal neurogenesis. The study evaluated cognitive function, neural damages, and hippocampal neurogenesis.

Polygala tenuifolia is a traditional Chinese medicine with multiple neuroprotective properties. Alzheimer's disease is the most common dementia worldwide, and to date the disease lacks satisfactory drug or therapeutic strategies. Further clinical research is warranted, as Polygala ...

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